Encapsulation of exemestane in polycaprolactone nanoparticles: optimization, characterization, and release kinetics

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Encapsulation of exemestane in polycaprolactone nanoparticles: optimization, characterization, and release kinetics

This study was aimed at developing a polymeric drug delivery system for a steroidal aromatase inhibitor, exemestane (exe) intended for sustained targeted delivery of drug through intravenous route. Carboxylated polycaprolactone (cPCL) was synthesized by ring opening polymerization of caprolactone. Exe-loaded cPCL nanoparticles (NPs) were prepared by interfacial deposition of preformed polymer a...

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ژورنال

عنوان ژورنال: Cancer Nanotechnology

سال: 2013

ISSN: 1868-6958,1868-6966

DOI: 10.1007/s12645-013-0037-4